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KMID : 0880220150530080487
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Journal of Microbiology
2015 Volume.53 No. 8 p.487 ~ p.494
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Regulation of Escherichia coli RNase III activity
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Lim Bo-Ram
Sim Min-Ji
Lee Ho-Woon
Hyun Seo-Gang
Lee Young-Hoon
Hahn Yoon-Soo
Shin Eun-Kyoung
Lee Kang-Seok
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Abstract
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Bacterial cells respond to changes in the environment by adjusting their physiological reactions. In cascades of cellular responses to stresses of various origins, rapid modulation of RNA function is known to be an effective biochemical adaptation. Among many factors affecting RNA function, RNase III, a member of the phylogenetically highly conserved endoribonuclease III family, plays a key role in posttranscriptional regulatory pathways in Escherichia coli. In this review, we provide an overview of the factors affecting RNase III activity in E. coli.
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KEYWORD
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RNase III, mRNA stability, regulator, catalytic mechanism, stress response, osmotic stress
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